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Doubly Deprotonated Allylacetophenone. First Example of a “Direct” E 5 Synthon
Author(s) -
Pohmakotr Manat,
Seebach Dieter
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197703201
Subject(s) - synthon , electrophile , deprotonation , adduct , derivative (finance) , chemistry , medicinal chemistry , stereochemistry , organic chemistry , ion , economics , catalysis , financial economics
The first unsaturated carbonyl derivative to react at C‐5 with electrophiles is the dianion (1) . It forms adducts (2) or (3) which can be cyclized to tetrahydrofurans or‐ pyrans if they contain OH groups.