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Facile Synthesis of Arabinoadenosine 3′‐Phosphate
Author(s) -
Mengel Rudolf,
Wiedner Harald
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197703171
Subject(s) - phosphoric acid , phosphate , nucleoside , oligonucleotide , ring (chemistry) , block (permutation group theory) , chemistry , combinatorial chemistry , biochemistry , organic chemistry , dna , mathematics , geometry
Arabinoadenosine 3′‐phosphate (2) can be obtained from (1) by ring opening with phosphoric acid in HMPT. Compound (2) could serve as an “arabino” building block for oligonucleotide syntheses; the phosphate‐free nucleoside inhibits some enzymes, viruses, and animal tumors.