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Serious Detonation during the Preparation of tert ‐Butyl‐oxycarbonyl Azide (Boc‐Azide)
Author(s) -
Feyen Peter
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197701151
Subject(s) - azide , hydrazide , reagent , chemistry , detonation , ether , medicinal chemistry , organic chemistry , explosive material
Caution with Boc azide! A serious explosion recently occurred during the preparation of t BuOCON 3 (Boc azide) from the hydrazide (1) and HNO 2 in ether. The reason is not known. It is urgently recommended that other reagents be employed for introducing the Boc protecting group.