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Tertiary Phosphane/Tetrachloromethane, a Versatile Reagent for Chlorination, Dehydration, and PN Linkage
Author(s) -
Appel Rolf
Publication year - 1975
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197508011
Subject(s) - reagent , phosphonium salt , chemistry , phosphonium , chloride , phosphorane , substrate (aquarium) , medicinal chemistry , derivative (finance) , salt (chemistry) , phosphorus , dehydration , phosphoryl chloride , wittig reaction , organic chemistry , biochemistry , oceanography , financial economics , economics , geology
In this review the processes occurring on the treatment of triphenylphosphane with tetrachloromethane are first reported; a key role is played here by (trichloromethyl)phosphonium chloride which reacts with a further amount of the phosphane to give the stable salt [chloro(triphenylphos‐phoranediyl)methyl]triphenylphosphonium chloride by way of dichlorophosphorane and (dichloromethylene)phosphorane that is detectable only as an intermediate. The preparative application of the two‐component system as a chlorinating, dehydrating, and P—N‐linking reagent is ascribable to “phosphorylation” Here and below, “phosphorylation” is used lo mean in general the formation of a phosphorus derivative. In the narrower sense this term denotes the introduction of phosphoryl groups P(O). of the substrate in question through several reactive species. In these applications the reactions with the substrate compete with reactions of the two‐component system with itself, so that the overall course of the reaction is in nearly all cases much more complex than was previously assumed. Nevertheless. very good results can be achieved by the use of this reagent, high yields and mild reaction conditions being characteristic.