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Tetracyclines: Chemistry, Biochemistry, and Structure‐Activity Relations
Author(s) -
Dürckheimer Walter
Publication year - 1975
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197507211
Subject(s) - tetracycline , chemistry , mode of action , steric effects , antibiotics , biochemistry , pharmacology , biochemical engineering , stereochemistry , biology , engineering
Abstract Tetracycline antibiotics continue to play an important role in human and veterinary medicine and in animal nutrition. The classical tetracyclines obtained by fermentation have been supplemented by products of partial synthesis which provide, in particular, the advantages of better pharmacokinetic properties and greater tolerance. Following a brief review of older work, the present article describes partial and total syntheses of tetracyclines, the influence of electronic, steric, and lipophilic factors and of complex formation on biological activity. The inhibition of biochemical systems invoked in interpretation of the mode of action of tetracyclines and problems involved in the development of resistance are discussed.