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Detection of Fragment Genesis in the Mass Spectrometer: DADI Mass Spectrometry as an Aid in the Structure Analysis of Organic Compounds
Author(s) -
Schlunegger Urs Peter
Publication year - 1975
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197506791
Subject(s) - mass spectrometry , fragmentation (computing) , chemistry , molecule , spectrometer , analytical chemistry (journal) , mass , ion , mass spectrum , chromatography , physics , organic chemistry , optics , operating system , computer science
“ Direct Analysis of Daughter Ions ” (DADI) can be carried out with commercial mass spectrometers embodying the Nier‐Johnson inverse geometry. DADI measurements permit experimental detection of the consecutive formation of molecule fragments (fragment genesis). Knowledge of fragment genesis enables the chemist to clarify the fragmentation processes of molecule‐ions and provides information on the structure of fragments formed in the mass spectrometer. In combination with classical mass spectrometry such information makes it easier to determine the structure of compounds, to analyze mixtures, to determine the sequence in periodically constructed molecules, for example oligopeptides, and to study rearrangement reactions occurring in the mass spectrometer.