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Prescriptions and Ingredients for Controlled CC Bond Formation with Organometallic Reagents. New synthetic methods (5)
Author(s) -
Schlosser Manfred
Publication year - 1974
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197407011
Subject(s) - reagent , alkylation , olefin fiber , stereoselectivity , chemistry , combinatorial chemistry , catalysis , organic chemistry , group 2 organometallic chemistry , grignard reagent , carbon fibers , molecule , computer science , algorithm , composite number
Merits and drawbacks of known carbon‐carbon linking procedures are outlined. Two novel methods are discussed in some detail: the copper‐catalyzed alkylation of Grignard reagents and reactions with allylpotassium compounds. Both methods provide a very efficient access to saturated, unsaturated, as well as functionally substituted hydrocarbons and moreover permit an astonishing degree of regio‐ and stereoselective control of olefin synthesis.