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Phase‐Transfer Catalyzed Two‐Phase Reactions in Preparative Organic Chemistry
Author(s) -
Dehmlow Eckehard V.
Publication year - 1974
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197401701
Subject(s) - phosphonium , chemistry , catalysis , nucleophile , carbene , wittig reaction , organic chemistry , organic reaction , hydrolysis , phase (matter) , phase transfer catalyst , ammonium
Quaternary ammonium and phosphonium salts catalyze reactions between substances located partly in an aqueous and partly in an organic phase. Use of such phase‐transfer catalysts simplifies and accelerates numerous reactions traditionally conducted in nonaqueous media. These reactions include carbene reactions, nucleophilic substitutions, alkylations of ketones and nitriles, Wittig and Darzens reactions, formation of ethers and esters. Other reactions such as hydrolysis and oxidation can be accelerated.