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Asymmetric Syntheses with the Aid of Homogeneous Transition Metal Catalysts
Author(s) -
Bogdanović Borislav,
Henc Biserka,
Lösler Arnold,
Meister Burkhard,
Pauling Horst,
Wilke Günther
Publication year - 1973
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197309541
Subject(s) - catalysis , asymmetric hydrogenation , homogeneous , rhodium , transition metal , halide , chemistry , metal , homogeneous catalysis , combinatorial chemistry , polymer chemistry , organic chemistry , enantioselective synthesis , physics , thermodynamics
The progress made in the field of homogeneous catalysis during the last five to six years has led, inter alia , to the development of highly selective catalysts for asymmetric syntheses. Homogeneous asymmetric hydrogenation, using well defined transition metal catalysts, may be achieved with optical yields of 85 to 90% or more. Catalytic reactions, in which the chiral centers are generated by CC bond formation, can result in optical yields of 70 to 80%. The hydrogenation catalysts consist primarily of rhodium(I) complexes containing “Homer phosphanes”, phosphanes with chiral C atoms, or optically active amides. Catalysts which induce optical activity through the formation of CC bonds have been developed from π‐allylnickel halides, Lewis acids, and phosphanes containing chiral C atoms. The results obtained signify a breakthrough in an area of catalysis previously restricted to syntheses involving enzymes.