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Biochemistry of the Pteridines
Author(s) -
Rembold Heinz,
Gyure William L.
Publication year - 1972
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197210611
Subject(s) - lability , catabolism , anabolism , cofactor , metabolism , biochemistry , function (biology) , chemistry , biosynthesis , redox , isotopic labeling , biology , enzyme , microbiology and biotechnology , organic chemistry
Biochemical information about the ubiquitous pteridines has become generally available only within the last fifteen years. This delay can be traced to the chemical lability of these compounds and their small concentrations in organisms. New methods of isolation and isotopic techniques have provided data on the biosynthesis, anabolism, and catabolism of this class of compounds. Hydrogenated pteridines are recognized today as cofactors for various mixed function oxygenases and are involved in cellular electron transport. Further unknown catalytic functions for pteridines in cellular metabolism are indicated by their physiological activity, negative redox potentials, and histoautoradiographic data.