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The Chemistry of Carbenoids and Other Thermolabile Organolithium Compounds
Author(s) -
Köbrich Gert
Publication year - 1972
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197204731
Subject(s) - thermolabile , chemistry , intramolecular force , intermolecular force , reactivity (psychology) , organolithium compounds , molecule , combinatorial chemistry , organic chemistry , computational chemistry , ion , pathology , medicine , alternative medicine , deprotonation , enzyme
Organolithium compounds are thermally quite stable, despite their extremely high reactivity. Thermolability, i.e. the property of undergoing irreversible changes at low temperatures without the participation of molecules of a different kind, is associated with additional functional groups, which may be readily eliminated together with the metal cation, may cause intramolecular rearrangements, or may lead to intermolecular additions and substitutions involving several molecules of the same type. Thermolabile organolithium compounds have frequently been postulated or detected as intermediates of important reactions, and are therefore of theoretical and practical interest. If certain precautions are taken, it is occasionally possible (mainly at low temperatures) to prepare them intact, and hence to release them from the constraint of the fate assigned to them as short‐lived intermediates. Investigations with this aim have for some time occupied a place of considerable importance in the chemistry of organometallic compounds.