Premium
Blood Coagulation and Fibrinolysis
Author(s) -
Heimburger Norbert,
Trobisch Heiner
Publication year - 1971
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197100851
Subject(s) - fibrinolysis , coagulation , chemistry , biochemistry , enzyme , substrate (aquarium) , medicine , biology , ecology
As a result of advances in protein chemistry it is now widely accepted that blood coagulation proceeds via a series of reaction steps of the nature of enzyme‐substrate reactions catalyzed by phospholipids. This also applies to the compensatory process of fibrinolysis. The factors taking part in both mechanisms as well as the inhibitors regulating the equilibrium have been shown to be proteins, some of them with a high carbohydrate content. Modern diagnostic methods and therapy are based on this knowledge.