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Detection of Hindered Rotation and Inversion by NMR Spectroscopy
Author(s) -
Kessler Horst
Publication year - 1970
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197002191
Subject(s) - conformational isomerism , nuclear magnetic resonance spectroscopy , chemistry , molecule , spectroscopy , inversion (geology) , spectral line , nmr spectra database , computational chemistry , chemical physics , stereochemistry , physics , organic chemistry , quantum mechanics , paleontology , structural basin , biology
Rotations and inversions in organic molecules are readily recognizable from the temperature dependence of the NMR spectra. The study of the effects of substituents on the activation barriers of such processes permits the elucidation of reaction mechanisms, and the stability limits of isomers can also be determined. The knowledge of the stability limits is necessary for the specific synthesis of stable rotamers and invertomers.