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The Gabriel Synthesis of Primary Amines
Author(s) -
Gibson M. S.,
Bradshaw R. W.
Publication year - 1968
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.196809191
Subject(s) - phthalimides , primary (astronomy) , phthalimide , amine gas treating , chemistry , scope (computer science) , hydrolysis , organic chemistry , potassium , combinatorial chemistry , computer science , physics , astronomy , programming language
Reaction of potassium phthalimide with halogenoalkanes and with a variety of other alkylating agents leads to the N‐alkylphthalimide. N‐Substituted phthalimides may be converted into the corresponding primary amine by hydrolysis or hydrazinolysis. The scope and limitations of these reactions, which together constitute the Gabriel Synthesis of primary amines, are reviewed.