Antibiotics as Inhibitors of Nucleic Acid and Protein Synthesis | Zendy

Hartmann G. | Zendy; Behr W. | Zendy; Beissner K.A. | Zendy; Honikel K. | Zendy; Sippel A. | Zendy

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Antibiotics as Inhibitors of Nucleic Acid and Protein Synthesis

Author(s) -

Hartmann G.,

Behr W.,

Beissner K.A.,

Honikel K.,

Sippel A.

Publication year - 1968

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.196806931

Subject(s) - puromycin , antibiotics , chloramphenicol , nucleic acid , dna , rna , mode of action , in vitro , streptomycin , chromomycin a3 , protein biosynthesis , biochemistry , rifamycin , polynucleotide , chemistry , biology , microbiology and biotechnology , gene , chromatin , heterochromatin

The antibiotics of the rifamycin, actinomycin, chromomycin, and anthracycline groups have been found to be specific inhibitors for the DNA‐controlled synthesis of RNA in vitro. Streptomycin, chloramphenicol, and puromycin can specifically suppress certain steps in the biosynthesis of proteins. The investigation of the mode of action of such substances may help us to gain a better insight into the transmission of hereditary information.

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