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Antibiotics as Inhibitors of Nucleic Acid and Protein Synthesis
Author(s) -
Hartmann G.,
Behr W.,
Beissner K.A.,
Honikel K.,
Sippel A.
Publication year - 1968
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.196806931
Subject(s) - puromycin , antibiotics , chloramphenicol , nucleic acid , dna , rna , mode of action , in vitro , streptomycin , chromomycin a3 , protein biosynthesis , biochemistry , rifamycin , polynucleotide , chemistry , biology , microbiology and biotechnology , gene , chromatin , heterochromatin
Abstract The antibiotics of the rifamycin, actinomycin, chromomycin, and anthracycline groups have been found to be specific inhibitors for the DNA‐controlled synthesis of RNA in vitro. Streptomycin, chloramphenicol, and puromycin can specifically suppress certain steps in the biosynthesis of proteins. The investigation of the mode of action of such substances may help us to gain a better insight into the transmission of hereditary information.