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Mitochondrial Oxidative Phosphorylation
Author(s) -
Schatz G.
Publication year - 1967
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.196710351
Subject(s) - oxidative phosphorylation , chemiosmosis , mitochondrion , atp synthase , phosphorylation , respiration , uncoupling agents , phosphate , adenosine triphosphate , coupling (piping) , biophysics , chemistry , inner mitochondrial membrane , biochemistry , microbiology and biotechnology , biology , materials science , enzyme , anatomy , metallurgy
Mitochondria can form ATP from ADP and inorganic phosphate, the required energy being supplied by respiration. This coupled process, which in sufficiently aerated normal animal cells furnishes the bulk of the cellular ATP, is termed oxidative phosphorylation. The overall reaction is intimately associated with the mitochondrial inner membrane and proceeds via a primary high‐energy intermediate. This intermediate, in a manner as yet unknown, energizes the anhydride formation between ADP and inorganic phosphate. The coupling between respiration and ATP synthesis is mediated by proteins of the mitochondrial inner membrane which are known as “coupling factors”. The mechanism of oxidative phosphorylation is at present being discussed in terms of three hypotheses which are generally referred to as “chemical”, “chemiosmotic”, and “conformational” hypotheses. None of these hypotheses has as yet been experimentally verified.