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Synthesis and Reactions of the Alkynylamines
Author(s) -
Viehe H. G.
Publication year - 1967
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.196707671
Subject(s) - electrophile , nucleophile , reactivity (psychology) , combinatorial chemistry , chemistry , catalysis , organic chemistry , polar , physics , medicine , alternative medicine , pathology , astronomy
Alkynylamines RCCNR 1 2have been known for only a few years. They are stable compounds, some of which have now become commercially available. Their high reactivity toward electrophiles as well as toward nucleophiles (particularly on acid catalysis) makes them very versatile starting materials. An interesting practical application is their use as condensing agents in peptide syntheses. They are superior to dicycloexylcarbodiimide as dehydrating agents for organic acids. They condense with polar multiple bonds and dipolar systems to form cyclic structures.