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Heterolytic Fragmentation. A Class of Organic Reactions
Author(s) -
Grob C. A.,
Schiess P. W.
Publication year - 1967
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.196700011
Subject(s) - heterolysis , fragmentation (computing) , sulfur , organic molecules , chemistry , oxygen , cleavage (geology) , boron , halogen , molecule , computational chemistry , chemical physics , photochemistry , organic chemistry , materials science , catalysis , ecology , biology , alkyl , fracture (geology) , composite material
Heterolytic fragmentation is a widespread but neglected class of organic reactions. It involves the regulated cleavage of molecules containing certain combinations of atoms such as carbon, oxygen, nitrogen, sulfur, phosphorus, silicon, boron and halogens. Fragmentation reactions are useful in degradation and structure elucidation, some are also of preparative value. A knowledge of the structural and electronic requirements makes it possible to predict and influence the course of reactions. From a theoretical viewpoint the recognition of heterolytic fragmentation has lead to the classification and correlation of a large number of apparently diverse reactions. Selected cases are reviewed in this article.