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Recent Advances in the Total Synthesis of Steroids
Author(s) -
Velluz L.,
Valls J.,
Nominé G.
Publication year - 1965
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.196501811
Subject(s) - total synthesis , stereoselectivity , steroid , chemistry , convergence (economics) , hormone , combinatorial chemistry , organic chemistry , biochemistry , catalysis , economics , economic growth
In the total synthesis of steroids on the industrial scale, three factors are important: stereoselectivity of the reactions used, resolution of racemic intermediates at the earliest possible stage, and convergence of the synthesis. Theoretical advances and wider practical experience in the chemistry of polycyclic compounds have recently led to the development of the first syntheses which are suitable for the industrial production of steroid hormones.