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Proton Transfer, Acid‐Base Catalysis, and Enzymatic Hydrolysis. Part I: ELEMENTARY PROCESSES
Author(s) -
Eigen M.
Publication year - 1964
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.196400011
Subject(s) - chemistry , elementary reaction , catalysis , enzyme catalysis , organic base , proton , base (topology) , acid catalysis , hydrogen bond catalysis , combinatorial chemistry , organic reaction , organic chemistry , computational chemistry , organocatalysis , kinetics , physics , enantioselective synthesis , mathematics , mathematical analysis , quantum mechanics
The proton occupies a special position as a promoter and mediator in chemical reactions occurring in solution. Many reactions in organic chemistry are catalysed by acids or bases; likewise, most enzymes contain active groups which promote acid‐base catalysis. To understand the reaction mechanisms involved, it is necessary to identify the elementary steps as well as their course in time. Systematic investigation of these elementary steps as well as their course in time. Systematic investigation of these elementary steps has become possible only with the development of new methods for studying very fast reactions. The present paper reviews the information obtained in this type of investigation. The result is a relatively complete picture of the elementary proton transfer mechanisms and a comprehensive description of the modes and laws of acid‐base and enzymatic catalysis.

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