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Enantio‐ and Regioselective Palladium(II)‐Catalyzed Dioxygenation of (Aza‐)Alkenols
Author(s) -
Giofrè Sabrina,
Molteni Letizia,
Nava Donatella,
Lo Presti Leonardo,
Beccalli Egle Maria
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202109312
Subject(s) - hypervalent molecule , regioselectivity , chemistry , stereoselectivity , oxazoline , palladium , ligand (biochemistry) , stereochemistry , catalysis , iodine , organic chemistry , biochemistry , receptor
An oxidative Pd‐catalyzed intra‐intermolecular dioxygenation of (aza‐)alkenols has been reported, with total regioselectivity. To study the stereoselectivity, different chiral ligands as well as different hypervalent‐iodine compounds have been compared. In particular, by using a C‐6 modified pyridinyl‐oxazoline (Pyox) ligand and hypervalent iodine bearing an aromatic ring, an excellent enantio‐ and diastereoselectivity has been achieved.