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Large‐Scale Synthesis of Functionalized Nanowires to Construct Nanoelectrodes for Intracellular Sensing
Author(s) -
Wu WenTao,
Jiang Hong,
Qi YuTing,
Fan WenTing,
Yan Jing,
Liu YanLing,
Huang WeiHua
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202106251
Subject(s) - nanowire , nanotechnology , materials science , pedot:pss , nanoparticle , electrode , nanocomposite , electrochemistry , noble metal , surface modification , metal , chemical engineering , chemistry , layer (electronics) , metallurgy , engineering
A strategy for one‐pot and large‐scale synthesis of functionalized core–shell nanowires (NWs) to high‐efficiently construct single nanowire electrodes is proposed. Based on the polymerization reaction between 3,4‐ethylenedioxythiophene (EDOT) and noble metal cations, manifold noble metal nanoparticles‐polyEDOT (PEDOT) nanocomposites can be uniformly modified on the surface of any nonconductive NWs. This provides a facile and versatile approach to produce massive number of core–shell NWs with excellent conductivity, adjustable size, and well‐designed properties. Nanoelectrodes manufactured with such core–shell NWs exhibit excellent electrochemical performance and mechanical stability as well as favorable antifouling properties, which are demonstrated by in situ intracellular monitoring of biological molecules (nitric oxide) and unraveling its relevant unclear signaling pathway inside single living cells.