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Spatial Order of Functional Modules Enabling Diverse Intracellular Performance of Fluorescent Probes
Author(s) -
Duan Chong,
Hu JingJing,
Liu Rui,
Dai Jun,
Duan Mojie,
Yuan Lizhen,
Xia Fan,
Lou Xiaoding
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202106195
Subject(s) - modular design , tetraphenylethylene , internalization , computer science , intracellular , fluorescence , chemistry , biophysics , physics , cell , biology , biochemistry , aggregation induced emission , quantum mechanics , operating system
To overcome a series of challenges in tumor therapy, modular‐agent probes (MAPs) comprised of various functional modules have been proposed. Researchers have tried to optimize the MAPs by exploiting the new modules or increasing the numbers of module, while neglecting the configuration of various modules. Here, we focus on the different spatial arrangements of existing modules. By utilizing a tetraphenylethylene (TPE) derivative with stereochemical structure and dual modifiable end‐group sites as small molecule scaffold, two MAPs with same modular agents (module T for enhancing the internalization of MAPs by tumor cells and module M for causing mitochondrial dysfunction) but different spatial arrangements (on the one side, TM‐AIE, and two sides, T‐AIE‐M, of the molecule scaffold) are designed. T‐AIE‐M with larger RGD binding angle performed higher specificity, while TM‐AIE characterizing longer α‐helix structure displayed superior toxicity.