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Intermolecular [5+2] Annulation between 1‐Indanones and Internal Alkynes by Rhodium‐Catalyzed C–C Activation
Author(s) -
Zhang Rui,
Xia Ying,
Dong Guangbin
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202106007
Subject(s) - annulation , rhodium , chemistry , intermolecular force , cycloaddition , catalysis , ligand (biochemistry) , limiting , transition state , reaction mechanism , functional group , combinatorial chemistry , stereochemistry , medicinal chemistry , molecule , organic chemistry , mechanical engineering , biochemistry , receptor , engineering , polymer
Herein, we report a [5+2] cycloaddition between readily accessible 1‐indanones and internal alkynes through Rh‐catalyzed activation of less strained C−C bonds. The reaction is enabled by a strongly σ‐donating NHC ligand and a carefully modified temporary directing group. A wide range of functional groups is tolerated, and the method provides straightforward access to diverse benzocycloheptenones that are hard to access otherwise. DFT studies of the reaction mechanism imply the migration insertion as the turnover‐limiting step and suggest beneficial π–π interactions in the transition states.