Enantioselective Addition of Pyrazoles to Dienes ** | Zendy

Jiu Alexander Y. | Zendy; Slocumb Hannah S. | Zendy; Yeung Charles S. | Zendy; Yang XiaoHui | Zendy; Dong Vy M. | Zendy

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Enantioselective Addition of Pyrazoles to Dienes **

Author(s) -

Jiu Alexander Y.,

Slocumb Hannah S.,

Yeung Charles S.,

Yang XiaoHui,

Dong Vy M.

Publication year - 2021

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.202105679

Subject(s) - enantioselective synthesis , hydroamination , regioselectivity , chemistry , allylic rearrangement , diene , ligand (biochemistry) , pyrazole , stereochemistry , combinatorial chemistry , catalysis , organic chemistry , receptor , biochemistry , natural rubber

We report the first enantioselective addition of pyrazoles to 1,3‐dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd 0 ‐catalyzed ligand‐to‐ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and advances the field of diene hydrofunctionalization.

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