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Enantiospecific Detection of D‐Amino Acid through Synergistic Upconversion Energy Transfer
Author(s) -
Tang Yongan,
Zhong Xiaoyan,
Yan Shuangqian,
Liu Xiaowang,
Cheng Liang,
Wang Yu,
Liu Xiaogang
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202105297
Subject(s) - nanoprobe , photon upconversion , limiting , detection limit , nanotechnology , energy transfer , chemistry , in vivo , amino acid , combinatorial chemistry , materials science , nanoparticle , biochemistry , biology , organic chemistry , mechanical engineering , ion , microbiology and biotechnology , chromatography , molecular physics , engineering
D‐amino acids (DAAs) are indispensable in regulating diverse metabolic pathways. Selective and sensitive detection of DAAs is crucial for understanding the complexity of metabolic processes and managing associated diseases. However, current DAA detection strategies mainly rely on bulky instrumentation or electrochemical probes, limiting their cellular and animal applications. Here we report an enzyme‐coupled nanoprobe that can detect enantiospecific DAAs through synergistic energy transfer. This nanoprobe offers near‐infrared upconversion capability, a wide dynamic detection range, and a detection limit of 2.2 μM, providing a versatile platform for in vivo noninvasive detection of DAAs with high enantioselectivity. These results potentially allow real‐time monitoring of biomolecular handedness in living animals, as well as developing antipsychotic treatment strategies.