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Bioorthogonal Azide–Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes
Author(s) -
GutiérrezGonzález Alejandro,
Destito Paolo,
Couceiro José R.,
PérezGonzález Cibran,
López Fernando,
Mascareñas José L.
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202103645
Subject(s) - bioorthogonal chemistry , cycloaddition , ruthenium , azide , chemistry , combinatorial chemistry , alkyne , catalysis , click chemistry , photochemistry , organic chemistry
Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide–thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium‐based technology and the standard copper‐catalyzed azide–alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonal.