Premium
Enantioselective Copper‐Catalyzed Borylative Cyclization for the Synthesis of Quinazolinones
Author(s) -
Dherbassy Quentin,
Manna Srimanta,
Shi Chunling,
Prasitwatcharakorn Watcharapon,
Crisenza Giacomo E. M.,
Perry Gregory J. P.,
Procter David J.
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202103259
Subject(s) - stereocenter , enantioselective synthesis , copper , catalysis , chemistry , combinatorial chemistry , molecule , stereochemistry , organic chemistry
Quinazolinones are common substructures in molecules of medicinal importance. We report an enantioselective copper‐catalyzed borylative cyclization for the assembly of privileged pyrroloquinazolinone motifs. The reaction proceeds with high enantio‐ and diastereocontrol, and can deliver products containing quaternary stereocenters. The utility of the products is demonstrated through further manipulations.