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Electrochemical Modulation of Carbon Monoxide‐Mediated Cell Signaling
Author(s) -
Park Jimin,
Zeng Joy S.,
Sahasrabudhe Atharva,
Jin Kyoungsuk,
Fink Yoel,
Manthiram Karthish,
Anikeeva Polina
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202103228
Subject(s) - carbon monoxide , chemistry , electrocatalyst , electrochemistry , signal transduction , electrochemical reduction of carbon dioxide , cell signaling , extracellular , carbon monoxide dehydrogenase , second messenger system , biophysics , nanotechnology , microbiology and biotechnology , biochemistry , catalysis , electrode , materials science , biology
Despite the critical role played by carbon monoxide (CO) in physiological and pathological signaling events, current approaches to deliver this messenger molecule are often accompanied by off‐target effects and offer limited control over release kinetics. To address these challenges, we develop an electrochemical approach that affords on‐demand release of CO through reduction of carbon dioxide (CO 2 ) dissolved in the extracellular space. Electrocatalytic generation of CO by cobalt phthalocyanine molecular catalysts modulates signaling pathways mediated by a CO receptor soluble guanylyl cyclase. Furthermore, by tuning the applied voltage during electrocatalysis, we explore the effect of the CO release kinetics on CO‐dependent neuronal signaling. Finally, we integrate components of our electrochemical platform into microscale fibers to produce CO in a spatially‐restricted manner and to activate signaling cascades in the targeted cells. By offering on‐demand local synthesis of CO, our approach may facilitate the studies of physiological processes affected by this gaseous molecular messenger.