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Configuration Sampling With Five‐Membered Atropisomeric P , N ‐Ligands
Author(s) -
Dahiya Gaurav,
Pappoppula Mukesh,
Aponick Aaron
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202102642
Subject(s) - enantioselective synthesis , steric effects , chemistry , ligand (biochemistry) , stereochemistry , combinatorial chemistry , atropisomer , catalysis , organic chemistry , receptor , biochemistry
Here we report a strategy for the systematic variation of atropisomeric C 1 ‐symmetric P,N ligands to incrementally change the position of the groups within the chiral pocket without modifying their steric parameters. More specifically, the effects of systematic modification of the nitrogen heterocycle in atropisomeric C 1 ‐symmetric stack ligands have been investigated in this study. The versatility and applicability of this approach has been demonstrated in mechanistically distinct catalytic enantioselective transformations, resulting in the identification of a P,N‐ligand for a highly enantioselective synthesis of organoboranes.