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An Aromatic Micelle‐Based Saccharide Cluster with Changeable Fluorescent Color and its Protein Interactions
Author(s) -
Narita Haruna,
Catti Lorenzo,
Yoshizawa Michito
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202102547
Subject(s) - fluorescence , chemistry , amphiphile , micelle , photochemistry , biophysics , organic chemistry , copolymer , aqueous solution , polymer , quantum mechanics , biology , physics
To develop a new type of synthetic saccharide clusters with changeable fluorescent colors, we herein designed a multisaccharide‐coated aromatic micelle. The new cluster forms in water through the quantitative assembly of bent polyaromatic amphiphiles bearing three mannose groups. The spherical assembly, with a 2 nm‐sized polyaromatic core and ca. 18 saccharide pendants, is stable even under high dilution conditions (up to 0.02 mM). The emission intensity and color of the saccharide cluster can be altered from moderate blue ( Φ F =19 %) to strong red, orange, and green ( Φ F up to 67 %) upon encapsulation of hydrophobic fluorescent dyes in water. Moreover, the present fluorescent clusters, both with and without the dyes, display selective interactions with mannose‐binding proteins in vitro.