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Regio‐ and Diastereoselective Copper‐Catalyzed Carbomagnesiation for the Synthesis of Penta‐ and Hexa‐Substituted Cyclopropanes
Author(s) -
Cohen Yair,
Augustin André U.,
Levy Laura,
Jones Peter G.,
Werz Daniel B.,
Marek Ilan
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202102509
Subject(s) - stereocenter , vicinal , hexa , chemistry , copper , catalysis , regioselectivity , stereochemistry , enantioselective synthesis , combinatorial chemistry , medicinal chemistry , organic chemistry
Despite the highly strained nature of cyclopropanes possessing three vicinal quaternary carbon stereocenters, the regio‐ and diastereoselective copper‐catalyzed carbomagnesiation reaction of cyclopropenes provides an easy and efficient access to these novel persubstituted cyclopropyl cores with a complete regio‐ and diastereoselectivity.