Premium
Multi‐Mode Reconfigurable DNA‐Based Chemical Reaction Circuits for Soft Matter Computing and Control
Author(s) -
Tang Qian,
Lai Wei,
Wang Peipei,
Xiong Xiewei,
Xiao Mingshu,
Li Li,
Fan Chunhai,
Pei Hao
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202102169
Subject(s) - electronic circuit , computer science , dna computing , dna , smart material , intramolecular force , nanotechnology , chemical reaction , materials science , chemistry , electrical engineering , engineering , biochemistry , stereochemistry
Abstract Developing smart material systems for performing different tasks in diverse environments remains challenging. Here, we show that by integrating stimuli‐responsive soft materials with multi‐mode reconfigurable DNA‐based chemical reaction circuits (D‐CRCs), it can control size change of microgels with multiple reaction pathways and adapt expansion behaviors to meet diverse environments. We first use pH‐responsive intramolecular conformational switches for regulating DNA strand displacement reactions (SDRs). The ability to regulate SDRs with tunable pH‐dependence allows to build dynamic chemical reaction networks with diverse reaction pathways. We confirm that the designed DNA switching circuits are reconfigurable at different pH and perform different logic operations, and the swelling of DNA switching circuit‐integrated microgel systems can be programmably directed by D‐CRCs. Our approach provides insight into building smart responsive materials and fabricating autonomous soft robots.