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A Cysteine‐Mediated Synthesis of Red Phosphorus Nanosheets
Author(s) -
Mo Jianbin,
Xu Yun,
Zhu Longqian,
Wei Wei,
Zhao Jing
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202101486
Subject(s) - phosphorus , nanomaterials , reagent , chemistry , reactive oxygen species , nanotechnology , cysteine , black phosphorus , dna damage , combinatorial chemistry , materials science , dna , organic chemistry , biochemistry , enzyme , optoelectronics
Among phosphorus‐based nanomaterials, layered black phosphorus and violet phosphorus have been actively explored in the past decade. However, methods for the synthesis of red phosphorus nanosheets (RPNSs) is lacking, even though red phosphorus (RP) is commercially available at low cost and has excellent chemical stability at room temperature. We report an efficient strategy for fabrication of RPNSs and doped RPNSs using cysteine as a reducing reagent. Data from in vitro and in vivo studies suggested that RPNSs can trigger production of reactive oxygen species, DNA damage, and subsequent autophagy‐mediated cell death in a shape‐dependent manner. Our findings provide a method for construction of layered RP nanomaterials and they present a unique mechanism for the application of phosphorus‐based materials in nanomedicines.