Premium
Reorganization of Self‐Assembled DNA‐Based Polymers using Orthogonally Addressable Building Blocks **
Author(s) -
Gentile Serena,
Del Grosso Erica,
Prins Leonard J.,
Ricci Francesco
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202101378
Subject(s) - control reconfiguration , dna , supramolecular chemistry , rational design , polymer , nanotechnology , monomer , block (permutation group theory) , dna nanotechnology , computer science , chemistry , materials science , molecule , embedded system , mathematics , biochemistry , geometry , organic chemistry
Nature uses non‐covalent interactions to achieve structural dynamic reconfiguration of biopolymers. Taking advantage of the programmability of DNA/DNA interactions we report here the rational design of orthogonal DNA‐based addressable tiles that self‐assemble into polymer‐like structures that can be reconfigured by external inputs. The different tiles share the same sticky ends responsible for self‐assembly but are rationally designed to contain a specific regulator‐binding domain that can be orthogonally targeted by different DNA regulator strands. We show that by sequentially adding specific inputs it is possible to re‐organize the formed structures to display well‐defined distributions: homopolymers, random and block structures. The versatility of the systems presented in this study shows the ease with which DNA‐based addressable monomers can be designed to create reconfigurable micron‐scale DNA structures offering a new approach to the growing field of supramolecular polymers.