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Bio‐adhesive Nanoporous Module: Toward Autonomous Gating
Author(s) -
Jo Hyuna,
Kitao Takashi,
Kimura Ayumi,
Itoh Yoshimitsu,
Aida Takuzo,
Okuro Kou
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202017117
Subject(s) - nanopore , chemistry , covalent bond , adhesive , nanoporous , molecule , nanotechnology , gating , ion , chemical engineering , polymer chemistry , biophysics , materials science , organic chemistry , layer (electronics) , biology , engineering
Abstract Here we report a bio‐adhesive porous organic module ( Glue COF) composed of hexagonally packed 1D nanopores based on a covalent organic framework. The nanopores are densely decorated with guanidinium ion (Gu + ) pendants capable of forming salt bridges with oxyanionic species. Glue COF strongly adheres to biopolymers through multivalent salt‐bridging interactions with their ubiquitous oxyanionic species. By taking advantage of its strong bio‐adhesive nature, we succeeded in creating a gate that possibly opens the nanopores through a selective interaction with a reporter chemical and releases guest molecules. We chose calmodulin (CaM) as a gating component that can stably entrap a loaded guest, sulforhodamine B (SRB), within the nanopores ( CaM COF⊃SRB). CaM is known to change its conformation on binding with Ca 2+ ions. We confirmed that mixing CaM COF⊃SRB with Ca 2+ resulted in the release of SRB from the nanopores, whereas the use of weakly binding Mg 2+ ions resulted in a much slower release of SRB.