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Monomer Controlled Switchable Copolymerization: A Feasible Route for the Functionalization of Poly(lactide)
Author(s) -
Huang Yuezhou,
Hu Chenyang,
Zhou Yanchuan,
Duan Ranlong,
Sun Zhiqiang,
Wan Pengqi,
Xiao Chunsheng,
Pang Xuan,
Chen Xuesi
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202017088
Subject(s) - copolymer , polyester , surface modification , monomer , polymer chemistry , polymerization , polymer , lactide , materials science , propargyl , chemistry , combinatorial chemistry , organic chemistry , catalysis
Switchable polymerization is an attractive strategy to enable the sequential selectivity of multi‐block polyesters. Besides, these well‐defined multi‐block polyesters could enable further modification for wider applications. Herein, based on the reversible insertion of CO 2 by Salen‐Mn III , a new monomer controlled self‐switchable polymerization route was developed. Chemoselective ring opening copolymerization of O ‐carboxyanhydrides (OCAs) and lactide (LA) was explored without cocatalyst. The sequential conversion of OCAs and LA into the polymer chain could form multi‐block polyesters. Based on this strategy, a series of multi‐block polyesters with different pendant groups were synthesized. Furthermore, by modifying the propargyl‐containing copolymers with quaternary ammonium groups, we have realized antibacterial functionalization of PLA. These results imply the potential application of this strategy for the fabrication of functional polymers for biomedical applications.