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Visible‐Light‐Induced Intramolecular Double Dearomative Cycloaddition of Arenes
Author(s) -
Zhu Min,
Xu Hao,
Zhang Xiao,
Zheng Chao,
You ShuLi
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202016899
Subject(s) - intramolecular force , cycloaddition , indoline , chemistry , photochemistry , substrate (aquarium) , combinatorial chemistry , stereochemistry , catalysis , organic chemistry , oceanography , geology
Herein we report visible‐light‐induced intramolecular double dearomative cycloaddition of arenes. Compared with the well‐known photodimerization of arenes under ultraviolet irradiation, the current reactions are carried out under mild conditions and feature wide substrate scope. A large array of structurally‐diverse polycyclic indoline derivatives is afforded in high yields (up to 98 %) with exclusive diastereoselectivity (>20:1 dr) via dearomative [4+2] or [2+2] pathway.