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Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy
Author(s) -
Chen Wei,
Liu Chuang,
Ji Xiaoyuan,
Joseph John,
Tang Zhongmin,
Ouyang Jiang,
Xiao Yufen,
Kong Na,
Joshi Nitin,
Farokhzad Omid C.,
Tao Wei,
Xie Tian
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202016330
Subject(s) - sonodynamic therapy , photothermal therapy , nanomedicine , nanotechnology , nanocarriers , cancer therapy , materials science , drug delivery , nanomaterials , biocompatible material , nanoparticle , photodynamic therapy , cancer , chemistry , biomedical engineering , medicine , organic chemistry
Ultrasound (US)‐mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non‐invasiveness and high tissue‐penetrating depth. However, developing biocompatible nanomaterial‐based sonosensitizers with efficient SDT capability remains challenging. Here, we employed a liquid‐phase exfoliation strategy to obtain a new type of two‐dimensional (2D) stanene‐based nanosheets (SnNSs) with a band gap of 2.3 eV, which is narrower than those of the most extensively studied nano‐sonosensitizers, allowing a more efficient US‐triggered separation of electron (e − )‐hole (h + ) pairs for reactive oxygen species (ROS) generation. In addition, we discovered that such SnNSs could also serve as robust near‐infrared (NIR)‐mediated photothermal therapy (PTT) agents owing to their efficient photothermal conversion, and serve as nanocarriers for anticancer drug delivery owing to the inherent 2D layered structure. This study not only presents general nanoplatforms for SDT‐enhanced combination cancer therapy, but also highlights the utility of 2D SnNSs to the field of nanomedicine.