Bubble‐Propelled Janus Gallium/Zinc Micromotors for the Active Treatment of Bacterial Infections | Zendy

Lin Zhihua | Zendy; Gao Changyong | Zendy; Wang Daolin | Zendy; He Qiang | Zendy

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Bubble‐Propelled Janus Gallium/Zinc Micromotors for the Active Treatment of Bacterial Infections

Author(s) -

Lin Zhihua,

Gao Changyong,

Wang Daolin,

He Qiang

Publication year - 2021

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.202016260

Subject(s) - biocompatibility , zinc , gallium , janus , biodegradation , materials science , janus particles , nanotechnology , coating , chemical engineering , chemistry , organic chemistry , metallurgy , engineering

We report a bubble‐propelled Janus gallium/zinc (Ga/Zn) micromotor with good biocompatibility and biodegradability for active target treatment of bacteria. The Janus Ga/Zn micromotors are fabricated by asymmetrically coating liquid metal Ga on Zn microparticles and display self‐propulsion in simulated gastroenteric acid (pH 0.5) at a speed of up to 383 μm s −1 , propelled by hydrogen bubbles generated by the zinc–acid reaction. This motion of Ga/Zn micromotors is enhanced by the Ga–Zn galvanic effect. The Ga III cations produced from the degradation of Ga/Zn micromotors serve as a built‐in antibiotic agent. The movement improves the diffusion of Ga III and results in a significant increase of the antibacterial efficiency against H. pylori , compared with passive Ga microparticles. Such Ga/Zn micromotors combine the self‐propulsion, good biocompatibility and biodegradability, and Ga‐based antibacterial properties, providing a proof of concept for the active treatment of bacterial infections.

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