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Ruthenium‐Catalyzed Dehydrogenation Through an Intermolecular Hydrogen Atom Transfer Mechanism
Author(s) -
Huang Lin,
Bismuto Alessandro,
Rath Simon A.,
Trapp Nils,
Morandi Bill
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202015837
Subject(s) - dehydrogenation , catalysis , alkene , chemistry , ruthenium , intermolecular force , combinatorial chemistry , photochemistry , steric effects , ligand (biochemistry) , hydrogen atom , aryl , organic chemistry , molecule , alkyl , receptor , biochemistry
The direct dehydrogenation of alkanes is among the most efficient ways to access valuable alkene products. Although several catalysts have been designed to promote this transformation, they have unfortunately found limited applications in fine chemical synthesis. Here, we report a conceptually novel strategy for the catalytic, intermolecular dehydrogenation of alkanes using a ruthenium catalyst. The combination of a redox‐active ligand and a sterically hindered aryl radical intermediate has unleashed this novel strategy. Importantly, mechanistic investigations have been performed to provide a conceptual framework for the further development of this new catalytic dehydrogenation system.