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Highly Enantioselective Cobalt‐Catalyzed (3+2) Cycloadditions of Alkynylidenecyclopropanes
Author(s) -
Da Concepción Eduardo,
Fernández Israel,
Mascareñas José L.,
López Fernando
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202015202
Subject(s) - enantioselective synthesis , cobalt , annulation , alkyne , catalysis , bicyclic molecule , enantiomer , chemistry , combinatorial chemistry , enantiomeric excess , stereochemistry , organic chemistry
Low‐valent cobalt complexes equipped with chiral ligands can efficiently promote highly enantioselective (3+2) cycloadditions of alkyne‐tethered alkylidenecyclopropanes. The annulation allows to assemble bicyclic systems containing five‐membered rings in good yields and with excellent enantiomeric ratios. We also present a mechanistic discussion based on experimental and computational data, which support the involvement of Co I /Co III catalytic cycles.