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Catalytic Enantioselective Synthesis of Spirooxindoles by Oxidative Rearrangement of Indoles
Author(s) -
Qian Chenxiao,
Li Pengfei,
Sun Jianwei
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202015175
Subject(s) - enantioselective synthesis , catalysis , chemistry , kinetic resolution , oxidative phosphorylation , combinatorial chemistry , phosphoric acid , organocatalysis , organic chemistry , biochemistry
Oxidative rearrangement of indoles to access oxindoles has been used as a key step in complex molecule synthesis. We report a catalytic enantioselective variant of this transformation by chiral phosphoric acid catalysis, providing rapid access to a range of enantioenriched spirooxindoles. The high enantioselectivity is controlled by dynamic kinetic resolution.