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Controllable Self‐Assembly of Peptide‐Cyanine Conjugates In Vivo as Fine‐Tunable Theranostics
Author(s) -
Zheng Rui,
Yang Jia,
Mamuti Muhetaerjiang,
Hou DaYong,
An HongWei,
Zhao Yuliang,
Wang Hao
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202015126
Subject(s) - cyanine , peptide , chemistry , fluorescence , self assembly , residue (chemistry) , conjugate , molecule , quantum yield , combinatorial chemistry , biophysics , nanotechnology , materials science , organic chemistry , biochemistry , mathematical analysis , physics , mathematics , quantum mechanics , biology
The fabrication of functional assemblies with defined structures through controllable molecular packing under physiological conditions is challenging. Here, modularly designed peptide‐cyanine conjugates that intracellularly self‐assembly into 1D columnar superstructures with controlled cyanine aggregation were designed, and they exhibit distinct imaging or photothermal properties. The peptide backbone is cleaved by caspase‐3/7 after entering the cells. Then the self‐assembled residue, with a double cyanine substitution ( Pr‐2Cy ), forms a P helical column in which H‐aggregated cyanine dyes show 3.4‐fold photothermal conversion efficiency compared to free ones. The self‐assembled residue with a single cyanine substitution ( Pr‐1Cy ) forms a loose column, in which cyanine dyes with undefined structure have a fluorescence quantum yield of up to 9.5 % (emission at 819 nm in H 2 O). This work provides a simple way to modify in vivo self‐assembled peptides with functional molecules for achieving desired bio‐applications.