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Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions
Author(s) -
Wang Gaoji,
Angelovski Goran
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202014431
Subject(s) - chelation , chemistry , metal ions in aqueous solution , zinc , lanthanide , paramagnetism , ion , nuclear magnetic resonance , inorganic chemistry , organic chemistry , physics , quantum mechanics
Abstract Zinc ions play an important role in numerous crucial biological processes in the human body. The ability to image the function of Zn 2+ would be a significant asset to biomedical research for monitoring various physiopathologies dependent on its fate. To this end, we developed a novel Gd 3+ chelate that can selectively recognize Zn 2+ over other abundant endogenous metal ions and alter its paramagnetic properties. More specifically, this lanthanide chelate displayed an extraordinary increase in longitudinal relaxivity ( r 1 ) of over 400 % upon interaction with Zn 2+ at 7 T and 25 °C, which is the greatest r 1 enhancement observed for any of the metal ion‐responsive Gd‐based complexes at high magnetic field. A “turn‐on” mechanism responsible for these massive changes was confirmed through NMR and luminescence lifetime studies on a 13 C‐labeled Eu 3+ analogue. This molecular platform represents a new momentum in developing highly suitable magnetic resonance imaging contrast agents for functional molecular imaging studies of Zn 2+ .