Mild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine‐Based Palladacycle | Zendy

Takale Balaram S. | Zendy; Thakore Ruchita R. | Zendy; Casotti Gianluca | Zendy; Li Xaiohan | Zendy; Gallou Fabrice | Zendy; Lipshutz Bruce H. | Zendy

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Mild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine‐Based Palladacycle

Author(s) -

Takale Balaram S.,

Thakore Ruchita R.,

Casotti Gianluca,

Li Xaiohan,

Gallou Fabrice,

Lipshutz Bruce H.

Publication year - 2021

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.202014141

Subject(s) - stille reaction , aryl , triphenylphosphine , chemistry , catalysis , halide , nanoreactor , combinatorial chemistry , coupling reaction , reagent , organic chemistry , medicinal chemistry , alkyl

An inexpensive and new triphenylphosphine‐based palladacycle has been developed as a pre‐catalyst, leading to highly effective Stille cross‐coupling reactions in water under mild reaction conditions. Only 500–1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij‐30 in water.

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