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Diols Activation by Cu/Borinic Acids Synergistic Catalysis in Atroposelective Ring‐Opening of Cyclic Diaryliodoniums
Author(s) -
Zhao Kun,
Yang Shan,
Gong Qi,
Duan Longhui,
Gu Zhenhua
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202014127
Subject(s) - chemistry , ring (chemistry) , enantioselective synthesis , catalysis , organic chemistry , combinatorial chemistry , medicinal chemistry , polymer chemistry
A Cu‐catalyzed enantioselective ring‐opening alkoxygenation reaction of cyclic diaryliodonium salts and diols in the presence of borinic acids was reported. Tuning structure of borinic acids with six or five‐membered ring skeleton could selectively activate 1,2‐diols or 1,4‐diols. A catalytic cycle through a key ion pair model that accounts for the observed enantioselectivity was proposed.