Premium
Design and Applications of a SO 2 Surrogate in Palladium‐Catalyzed Direct Aminosulfonylation between Aryl Iodides and Amines
Author(s) -
Jia Xiuwen,
Kramer Søren,
Skrydstrup Troels,
Lian Zhong
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202014111
Subject(s) - aryl , palladium , chemistry , combinatorial chemistry , catalysis , functional group , organic chemistry , alkyl , polymer
A new SO 2 surrogate is reported that is cheap, bench‐stable, and can be accessed in just two steps from bulk chemicals. Essentially complete SO 2 release is achieved in 5 minutes. Eight established sulfonylation reactions proceeded smoothly by ex situ formation of SO 2 by utilizing a two‐chamber system in combination with the SO 2 surrogate. Furthermore, we report the first direct aminosulfonylation between aryl iodides and amines. Broad functional group tolerance is demonstrated, and the method is applicable to pharmaceutically relevant substrates, including heterocyclic substrates.