Premium
Synergetic Lipid Extraction with Oxidative Damage Amplifies Cell‐Membrane‐Destructive Stresses and Enables Rapid Sterilization
Author(s) -
Chen Yu,
Ji Qinghua,
Zhang Gong,
Liu Huijuan,
Qu Jiuhui
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202013593
Subject(s) - membrane , chemistry , sterilization (economics) , cell membrane , reactive oxygen species , biophysics , bacteria , oxidative stress , cell , molecule , escherichia coli , microbiology and biotechnology , biochemistry , biology , organic chemistry , genetics , monetary economics , economics , foreign exchange market , foreign exchange , gene
Here, we introduce an innovative “poison arrowhead” approach for disinfection based on a nanosheet bacterial inactivation system that acts synergistically to achieve sterilization rates of >99.99 % ( Escherichia coli ) over an ultrashort time period (≈0.5 min). The two‐dimensional MoS 2 “arrowhead” configuration has a sharp edge structure that enables the vigorous extraction of lipids from cell membranes and subsequent membrane disruptions. In the presence of permonosulfate, a strong oxidant, sulfur vacancies containing MoS 2 activate the stable molecules, which in turn produce reactive oxygen species (ROS) from edge sites to basal areas. This process not only scavenges some portion of the phospholipids to allow for MoS 2 surface refreshment but also directly attacks proteins thereby inflicting further damage to injured cells and amplifying the cell‐membrane‐destructive stresses toward pathogenic microorganisms. With small amounts of the new material, we successfully disinfected natural water (≈99.93 % inactivation in terms of total bacteria) within 30 s.