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Endogenous mRNA Triggered DNA‐Au Nanomachine for In Situ Imaging and Targeted Multimodal Synergistic Cancer Therapy
Author(s) -
Yu Sha,
Zhou Yang,
Sun Yao,
Wu Shaojun,
Xu Tingting,
Chang YuChung,
Bi Sai,
Jiang LiPing,
Zhu JunJie
Publication year - 2021
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202012801
Subject(s) - photothermal therapy , photodynamic therapy , in situ , chemistry , survivin , dna , photosensitizer , aptamer , cancer therapy , biophysics , nanotechnology , cancer research , cancer imaging , cancer , microbiology and biotechnology , materials science , apoptosis , biochemistry , biology , genetics , organic chemistry
The development of versatile nanotheranostic platforms that integrate both diagnostic and therapeutic functions have always been an intractable challenge in precise cancer treatment. Herein, an aptamer‐tethered deoxyribonucleic acids‐gold particle (Apt‐DNA‐Au) nanomachine has been developed for in situ imaging and targeted multimodal synergistic therapy of mammary carcinoma. Upon specifically internalized into MCF‐7 cells, the tumor‐related TK1 mRNA activates the Apt‐DNA‐Au nanomachine by DNA strand displacement cascades, resulting in the release of the fluorophore and antisense DNA as well as the aggregation of AuNPs for in situ imaging, suppression of survivin expression and photothermal therapy, respectively. Meanwhile, the controlled released drugs are used for chemotherapy, while under the laser irradiation the loaded photosensitizer produces reactive oxygen species (ROS) for photodynamic therapy. The results confirm that the proposed Apt‐DNA‐Au nanomachine provides a powerful nanotheranostic platform for in situ imaging‐guided combinatorial anticancer therapy.